Today on the Gut Health Reset Podcast, we are discussing the importance of Vitamin E in your body with Dr. Barrie Tan! Vitamin E, a powerful antioxidant found in many foods, is gaining recognition for its positive effect on gut health. Studies suggest that Vitamin E can influence certain gut bacteria which helps to restore and maintain gut health. Since gut issues only stand to increase amidst the modern lifestyle of processed foods, Vitamin E may offer us an easy way to combat these problems before they start. By restoring gut balance it appears that Vitamin E can improve not just gut health, but overall wellbeing as well.
We will answer these questions:
– Why did Dr. Tan begin researching Vitamin E?
– Why is Vitamin E so important for your gut health?
– Can Vitamin E be helpful for anti-aging?
– How can you tell if you’re Vitamin E deficient?
– And more!
Still want to learn more? Schedule with Dr. Barter today!
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About Dr. Barrie Tan:
Dr. Barrie Tan is hailed as a trailblazer and the world’s foremost expert on vitamin E. A scientist first and foremost, Dr. Tan earned his Ph.D. in Chemistry/Biochemistry from the University of Otago, New Zealand and spent several years as a professor at UMass. His research expertise includes lipid-soluble nutrients (carotenoids, E vitamers, CoQ10, and omega-3s) that impact chronic conditions. He was the first to introduce tocotrienols benefits to the nutrition industry and developed the first-ever tocopherol-free tocotrienol product derived from annatto. Dr. Tan continues to collaborate with numerous universities worldwide to further tocotrienol research. Beyond tocotrienol, Dr. Tan’s research now spans into geranylgeraniol, a critical endogenous nutrient for healthy aging.
Dr. Tan has held roles of Chief Scientific Officer and Scientific Board Member for multinational organizations. His career includes periods working in association with the US Armed Forces and a Prince of Thailand as well as being an internationally celebrated and sought-after speaker, having presented at multiple respected conferences in the field including; IFT, ADA, ASN, IHS, A4M, NPA, AACR, ICIM, AOCS, IAOMT, and the Academy of Nutrition and Dietetics. Renowned for his engaging warmth and gracious humor, Dr. Tan has also been featured in array of popular media including the Ben Greenfield and JJ Virgin podcasts.
Dr. Tan is currently the President of American River Nutrition, a natural health R&D company he started with his wife, Elizabeth, in 1998. Described as a scientific pioneer, his mission is simple, improve the everyday health of people’s lives.
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Dr. Ann-Marie Barter is a Functional Medicine and Chiropractic Doctor at Alternative Family Medicine & Chiropractic. She is the clinic founder of Alternative Family Medicine & Chiropractic that has two offices: one in Longmont and one in Denver. They treat an array of health conditions overlooked or under-treated by conventional medicine, called the “grey zone”. https://altfammed.com/
*As always, this podcast is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only. Please consult with your healthcare professional before making any changes to your current lifestyle.*
Today on the Gut Health Reset Podcast, we are gonna talk about why Vitamin E is very important for the gut, its role in inflammatory bowel i b, s, and even polyps. We’re also gonna talk about the benefits of vitamin E as we age. What is important to look for when you get a vitamin E supplement, when it begins to decline naturally, and how you can go.
Replacing it. Thank you so much for joining us here today on the Gut Health Reset Podcast. I’m your host, Dr. Ann-Marie Barter, and today I have Dr. Barrie Tan, who is hailed as a trailblazer in the world’s foremost expert on vitamin E. He’s a scientist, first and foremost. Dr. Tan earned his PhD in chemistry and biochemistry from the University of Otago in New Zealand, and spent several years as a professor at His research and expertise includes lipid soluble nutrients, including vitamin E, coq 10 and Omega three s that impact on chronic conditions.
He is also currently the president of the American River Nutrition and Natural Health r and d company. He started with his wife Elizabeth in 1998. He’s described as a scientific pioneer. His mission is simple to improve everyday health of people’s lives. Dr. Tan, thank you so much for being here today. I am super excited to have you on the podcast here, and, and you’re talking a lot about some nutrients that a lot of people do not talk about.
So what got you interested in research on Vitamin E?
Vitamin E thank you for inviting Vitamin E. Have interest off again on again, off again on again, but in my early days when I was a, a professor at the University of Massachusetts, I was very fascinated with lipid soluble vitamin such as the e A.
K and D And then E was a was the well-known one back in the 1930s and 40, and then k soon after they kind of disappeared. And then e came up in the 1970s and 80 petered away in 2000 because of studies that showed a vitamin E could potentially even be harmful. And then d came. And then now K came back after D.
So E is kind of like a little bit submerged from water, but my interest has been in it because I’m always interested in lipid soluble vitamin and E is one of them.
Got it. That sounds great. So we’ll come, kind of come back to, to some of the studies here but I first wanna hear about why vitamin E is important for the.
Okay, the gut in, in the gut if you hear of any gut inflammatory bio syndrome, Crohn’s disease and, and these things, the, the, the cause of these disease may not be a hundred percent known, but some of the symptoms of disease are often known and that oftentimes you hear the word is inflammation because the bad bugs would go up and a good bug go down, serious inflammation.
Fully as an antioxidant. So when something is a serious antioxidant, the inflammation would be contained and therefore it would be, in that sense alone, it would be exceedingly good for people that have gut problems.
How does it work with so you mentioned some of the inflammatory bowels. How have, has there been any research associated with i b s and vitamin.
Yes the, the one that I can think immediately of three, one would be somebody is studying a, a pre-cancerous condition of polyps. So they have this ib, kind of like an ibs where it’s a little bit off on the site of polyps to pre-cancerous. And they saw that when they did that, the, the poly.
Size and the polyps reduction is much better reduced. And then the polyp did not go to cancerous condition. In another study I see it’s clear, it is clearly i b s induced colon cancer, and they saw that the severity of the colon cancer in the animal is reduced. So those, and then the third one, my colleague in Texas did this when they gave people.
Toco, triol, vitamin E, not Toro, Toco, triol, vitamin E. The good, essentially the good bugs go up and the bad bugs go down. So there is a balance there. So in that sense, I see this very positive for the influence in the gut microbiome.
Wonderful, because we know that some of those cases, you know any of the inflammatory bowels, you know, it has been linked to nutrient deficiency and that is absolutely fascinating about the polyps.
That’s absolutely fascinating.
I, I, I, I know this is very, Literally very anal in this. Some people have nipped off the soft gel and, and apply it anally into it. We have no such study like that. We only gave the animal oral dose and they can help like this. But they, they were encouraged by a comment that I made in the interview to a group.
I don’t remember the group now. Their focus on colitis and they were. I said that in most of these vitamin E, because it’s lipid soluble, you, you take it with food so that it absorbs with only one exception. And the exception is if you have a a colon problem, you may not want all of the vitamin E toco try not to be absorbed.
Instead, you let it partially not absorb, so you slime through the colon and in that way, Able to dermatologically contact with the colon. So they picked it up and then they apply it. Suppository. I was amazed. I did not ask them to do that, but clearly these are. People who suffer from serious condition, they apply.
So I don’t know where that application is going, but, but probably in another half year, I will learn from the outcome of that application that they’re planning to do.
So what something interesting that I do in practice, which is along these same lines, is I give a vitamin E suppository anytime there’s bleeding or hemorrhoids and it just turns it right around.
So we do, wow. We do vitamin e suppos. You do it
anyway. Okay. So yes, so I would, I would say that, In animal study, we have done this Ann Marie, and it looked like it is very potent. Of course a most simplistic thing would be you, you, you have the patient take the toko triol purposefully, almost against my good judgment.
Without a meal on a empty stomach, and therefore this lipid soluble nutrient will not be normally absorbed. Some of them will still be like more like 10, 20% rather than 50, 60% absorbed. So therefore the 90% not absorbed will slim to the intestine and the gut, and in that way is able to in contact, help, their gut.
it’s, you’re right. It’s amazing. It does really work. So I know everybody is working on also trying to look as young as they possibly can. So how does Vitamin E help us with
aging? Okay. In, in the question you have maybe by intent or not, it’s partly loaded. When people say that they take vitamin E, they usually refer to skin help and a lot of of skincare product uses it.
But then your, your question also went deeper to ask about aging. I’ll answer the aging one in this way, and then you can apply to the skin and elsewhere. Each person. Of hundred and roughly hundred and 30 to 180 pound. I’m averaging like that in each person’s weight. We have about 38 trillion cells.
That’s a big number. 38 trillion cell, approximate to 5,000 times the population of the earth. Help us to contain the idea a little bit and each of those cells look something like a bean. And it has a cell wall that contain the nuclears, and then other things inside, like mitochondria for energy. All these things for each cell to work well.
The cell wall has to be fully functional where nutrients go in and then the waste would go out and in so doing I call, I exemplified this as a proper gated community. A community of organ nails inside. But if the gated community is not functioning well, the cell will begin. Age, it doesn’t really die. It begin to age and it become partially dysfunctional.
I know many people explain anti-aging differential. I try to explain it very simplistically and it helps on the cell wall. Now, 80% of the cell wall is actually fat. So when people say that they have 25, 30% fat, yes, they can hold onto their left handle or the butt like that. More than half of those fat, they cannot see that is in the cell wall.
Now that I explained this, how do I bring it back to the anti-aging thing? If you think of the three main food group, protein, fat, and carbohydrate, I don’t want any of them to get oxidized. And everybody said that their thing is an antioxidant. I’ll tell you how to cut the chase off of the meaning of antioxidant.
That is critical. Yes, it is true. I don’t want my, I don’t want my fat, carbohydrate, and protein to get oxidized, but of these three major groups, the easiest thing to get oxidized is. If you drive past a roadkill on a summer day, that smell, if you have a stick of butter on a hot summer day, come back two hours, you smell the stick of butter, that smell.
So if you have a hunk of steak out there or something like that, it doesn’t smell. Eventually it will go bad. And even the hunk of steak that go bad, the first part of the steak they go back will actually be a bit oxidized fat. So all this to say the lowest line fruit of fruit of things that go bad, Would be the fat.
Therefore, when you come back to the cell wall, 80% is fat. I care most that the fat would go bad so that the gate will not work properly and then the nutrient wouldn’t go in. Now have, now that I cut your, your audience attention. More than 90% of the antioxidant that land onto the cell wall. They are vitamin E molecule.
Yes, coq 10 is good. Yes, keratins are good, and yes, REL and E, G, C, G, all these are antioxidant, Lutin, Entin, but none of them. On the cell wall as well as the vitamin E molecule. So in the 1980 there was a famous professor, he extracted old antioxidant in the cell wall, and not surprisingly, more than 90% of those antioxidant in the cell wall, a vitamin E molecule.
So therefore, vitamin E is good to help in anti-aging because they protect the cell wall so that, so that the cell will perform the proper function. That’s it. So if the audience capture this and nothing else, then you gain the most and the simplistic form of what Vitamin E ought to do in the human body.
How do we know if we’re deficient in vitamin E? And then when do we start to become deficient, like based on our age?
Okay. I think this one I have to. All of us know vitamin E is an antioxidant, and we take it to protect our body. It is already off a bit from the original Discovery Alpha was known, to perform a bodily function.
And then because of that, it became the superstar status of vitamin and it just go from the letter. And then E was not taken, and therefore it became Vitamin E. But much of the audience, including myself, initial did not know Alpha, took Carro, became a vitamin. Not primarily because of his antioxidant property, though it is an antioxidant, it became a vitamin.
because it helped the fetus to full term, and I repeat this, it helped the fetus to full term. So therefore, vitamin E as about 15 milligram as alpha tocara is needed in a prenatal vitamin. For that reason alone. However, since the discovery exactly a hundred years ago by two pediatrician from uc, Berkeley that have long been forgotten, no few people know vitamin E as a birth vitamin, which in fact it it is as a vitamin, but it’s known mostly as a antioxidant, which it is also the antioxidant piece.
We don’t make vitamin in a human body, and vitamin E is made by the plant, particularly the plant to produce oil and fat. Therefore, vitamin E is gotten from soy and con corn because soy and corn contains a lot of fat and is protecting the oxidative damage. So you see if you clock it in and say, aha, if the plant make vitamin E to do that, and if we take vitamin E, it should protect our fat.
That’s it. If we got that, that’s a good concept. It’s not what is known for a vitamin, but it is. So now you ask the question, how do we know we have enough vitamin? When a person does not have enough vitamin E, their skin is patchy and very dry like that. But that other could be symptoms of vitamin C deficiency and other things as well.
But that’s the vitamin E. But by the time you get your skin very dry and patchy, Dr. Part Par bar that is already quite. So we want to know it sooner, and the sooner would be an alternative and forward looking chiropractor. Physician like that, like yourself. You do blood work. When you do blood work, you look for inflammation.
You look for oxidative damage to the fat. And sometime people look at the, the integrity of. Blood cell in the blood work. When they see that not doing well, then they say, okay, this person could be low in vitamin E. So usually that kind of vitamin E they’re referring to is Alpha Tora, which 95% of the vitamin E you find on the shelf is that.
I’m hoping that in this talk I’ll be able. To bring to the audience attention a new narrative, not the popular Toro, but the lesser known Toco trio that clearly have differentiated functions on Toro. So hopefully I answer your question in part.
So just one thing that I think is so interesting is to get a baby to full birth weight.
I, I’m seeing more and more kids be put on growth hormone. Was that a vitamin E deficiency? Initially? Potentially. Cuz that’s very, very common these days.
There is a, there is a hormone deficiency connection to vitamin E, but I have not seen that link. Very strong. The link to vitamin E is that when the fetus is growing, the, the fetus is one of the few.
Sorry, a few life form, not organ, because they’re already istic. The few life form that grow even faster than a tumor cell. That’s not the kind of discussion you want to talk to. An expected man, the tumor, like that. Mm-hmm. a cancer grow rapidly. But the feeders grow faster than the tumor, and in the growth of the feeders, the cell multiply, like met, so the cell multiply, like met the cell wall is growing like met like this, and, and the vitamin E is in the cell wall.
So when you have the cell going like met, you have to have enough vitamin E there to protect the cell wall. Same idea like that. So, however, when it come to tumor, It does the exact opposite. So when you have the cell wall growing, like remember the tumors also growing like man, and when you add those toco triol, vitamin E, it will directly kill the tumor cell that I know you’re probably not thinking about this.
When, when you were talking about Toco Triano, that. We found almost stunningly unusual of Toco Triol vitamin E. It directly go into the cell wall and it actually cause a, a, a prooxidant effect, and then it killed the tumor cell, whereby when we treat it to the normal cell of the patient, then it didn’t do normal cell other than as an antiox.
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If you visit dr annmarie barter.com and use the promo co podcast to get 10% off your next order. So what are you waiting for? Go visit Dr. Anne-Marie barter and get 10% off your supplement bundle. C and now back to our episode. Great. So you there, there’s been some recent news articles that have come out that have talked about vitamin E being harmful and dangerous for your health and some in a supplement to always avoid what is going on in those studies.
What, what, what are they discussing?
Thank you for asking that question. Those studies began in the 1990s and it kind of like died a royal death in 2010, in those 20 years. Because of the fame of vitamin E in Toro in the 1970s and eighties, a lot of money were pumped into doing this by the US government.
Done in Harvard medical school and the VA hospital, huge number of of people, the, the physician health. Professional study like that. In those studies, they were looking for men and women for cardiovascular health. For women, postmenopausal women. They’re normally healthy people, but because the study have 30, 40,000, People, they can sub segregate the study in the those who are smokers, not smokers, post-menopausal, not post all kinds of things.
Even when they sub sub it up, they still have two 3000 people so they can do those study. When those studies came out, they found that people who take two. Milligram or 200 iu, 400 iu, or 1000 IU like that. Instead of helping to improve cardiovascular health or adverse increase, increase cardiovascular health.
That’s not good news. But the worst news is potentially cause breast cancer in postmenopausal women. That’s a big alarm bell. And in men even increase prostate cancer and lung cancer on those who are smokers immediately the break was put on. But why is that? My theory is that those vitamin E that they talk about first, they’re s.
They’re referring to Alpha Toro. No. Toco. Triol and Alpha Toro among the vitamin E are the, is the only one that have a transport protein. So now I’m using a new phrase. What is the transport protein? If you think of. The, the nutrient we get in our body. Most of that goes through the cell wall to diffusion low low concentration, high concentration.
It diffused from high concentration to low concentration. You just have a spoon of sugar in your water. You don’t stir the water. You can see the wiggly thing. You go from high concentrate, that’s diffusion. When you have a transport protein, it is not diffusion anymore. It is a right to pass it. Just think of it, you have 1000 people allowed to go to the Oscar thing.
They line up the night before. They just have to wait in line. If you were to be Nicole Kitman, for example, you already have some Oscar like that. They don’t wait in line. They just go right through. That’s the right of passage. Transport protein. Mean that if a compound have a transport protein, they will have a right P passage.
They go right through. Alpha Toro is the only vitamin E. They have a right to passage, so when people take 400 milligram or 1000 milligram, they already. Take so much of this, even if by pure diffusion they would go in fast, but instead they have a right of passage, they go in like, man, nobody know of all this.
Alpha took offer when in what happened to them. Now the study show that it could cause the condition I mentioned to you, so that. Vitamin E thing just died of a royal death. So I feared in those 1990 and 2000 I was already studying Toco Triol, I’m gonna die with this. I’m like the baby with the bathwater thrown away.
But I persisted Dr. Bar in the last 20, 30 years to do Toco Triol study. We never. To trio to be toxic in all the 20 over clinical trials that we study on the myriad of chronic condition. I’ll just mention them and I’ll leave you to decide which one you want to pick me up. I’ll pick it up to say we study people with dyslipidemia, we study people with pre-diabetes.
Metabolic syndrome type two diabetes and a special condition of metabolic syndrome, fatty liver condition, and men and women with overweight and obesity. And finally a whole big class of people with cancer. But mostly these, a chronic condition we have, we have seen. That the different Toco trio differentiate from Toro functions that Toro does not do.
And we were never able to document chronic document safety issue like Toro that you brought to my attention to discuss.
So what were you seeing when you actually utilize natural forms of vitamin E? Because so many of people are afflicted with. You know, quite a few of these conditions.
But I’m just gonna pick out, you know, metabolic syndrome, which is kind of pre-diabetes. You have higher, you know, basically cholesterol, higher blood sugar, as well as you have, you have liver enzymes that have elevated. Yes. So those things. And then ultimately, you know, being overweight as well. So how does vitamin E.
Those two conditions, what are you noticing with.
We first studied this with people with hypercholesterolemia that didn’t have the other condition, and we saw that the cholesterol dropped a bit. But while we were looking at, in the lipid panel that you may have from your patient, I noticed, oh, the triglyceride also dropped.
So we did more study. The triglyceride consistently drop. So this is a part, it is a teaching moment. I hope that you allow me to do this . When, when Professor Gerald re. First came up with this metabolic thing, he call it syndrome X, because he didn’t know what this was. Gerald re have since retired and passed away from Stanford like that, and, and when he figured out, then he become metabolic syndrome.
Some of the audience may or may not know it. I met him one time when he was getting an award in American Diabetes Association on his way out to take a flight back, back, back to Stanford. He was a. Not happy that I stopped him, but, but, so he only gave me a, one sentence is you walk away with this, then you figure out what I mean.
So he just, so he simply said this
hypertriglyceridemia. Always precedes hyperglycemia in, in short, high triglyceride always come first before you have high sugar. Therefore, people will not become diabetic first in the metabolic syndrome. The triglyceride will go up, there will be the first sign something is going off like that, and we consistently saw the triglycine go down.
So now with those understanding of metabolics, so we decided to study people with. Diabetes. That means they’re not diabetic. They sugar get normal high. And we notice that the liver enzyme drop a little bit as you indicated. I, I call the liver enzyme drop a stress enzyme of the liver day drop. And then of course, since we are studying inflammation, so we study C-reactive protein, we have, we’ve done so many of this study, it is yearning to me, I just do it and it always, so the C reactive protein drop, but we also measure oxidized.
Remember I told you Toko trio oxide and the oxidized had dropped, so we saw that marker drop. Then we study, we decided to study people with fatty liver. They also have, metabolic syndrome is part of the whole cluster here. We were doing nuance study. The fat was in the liver. So we actually have ultrasound to map the fat.
The fat also egress from the liver. That is really good news. And then in the last study, we did three month study, a six month study, and finally we did 12 month study. This is so easy to stay my entire, nevermind everything I’ve done before, just the fatty livers. Three clinical trials we did is eight years off My.
Besides all the other stuff that I’ve talked to you before, so I, I just hone in on, just because the last thing we done in a 12 month study, we directly compare to Alpha Toro because people ask about Alpha Toro and the Toco Triol different group and the Toco Triol. The Alpha Toro works, but the Toco Trinal work above that of Alpha Toro in two things.
It reduce better the inflammation than that of Alpha Toro one. The second one I did not expect, actually, I notice this is in the three and six. But I saw this in 12 months, so I have to accept that this actually work. I was resisting because I know how people would read the study if I say it, but now I have to say at least in a three, six, and 12 month, these fatty liver metabolic syndrome people that are overweight, they cons, they consistently reduce weight.
The reduction of weight is typically 10 to 15 pound at. Six and 12 months, they consistently losses. So it’s sustainable. So therefore people are sure to ask me, is this a weight loss product? That’s the part that I’m really about in weight loss product. They usually see something in four weeks or less, or we don’t have data for four weeks or less, but we do have data at three, six and 12 one.
We. That Toco Triol help people to lose weight, not in and of itself a weight loss product, but the metabolism is so outta kilter, came back to kilter. Inflammation is reduced and therefore the adjustment of the body in the weight loss. If you, if I, that I can say, so if people want to say, do I lose weight or not?
If they say so black and white, then I say, So patient lost weight at three months, six months, and 12 months. So seemingly is also sustainable. So that to me, that is really icing on the cake. You know, I know it’s a bad metaphor, but it’s actually a, a good thing. We actually saw this, even though we did not expect this.
So where do we find this natural vitamin
E now. Okay. If you go on my web, our website, American River Nutrition, or you type my name Barry Tan, because I speak, I spoke on this so many time, you can easily track me down. We, we are the only. Place in the US to make Toko Trio. We extracted from a plant called Anto.
This beautiful plant here, Leonardo, if you touch it, I pretend to touch it. It’s stay in your finger. And those color from Anto is used for coloring cheese. So I removed the color and discover the vitamin E. And the vitamin E that I discovered from them. Surprisingly, it did not contain any Toro. Only Toco, triol, and the only other two sources I found is from Rice and Palm.
So if you were to go to the store to buy vitamin E, 90% or more of the time, the vitamin E would be Toro. So you have to put that aside. You look for Toco, triol, vitamin E, and you want it to say Anto. A N N A T T O. Anto, Toco Triano. But if you really want to hone in on, is this the Anto, that American River, may we just tradename it Delta Gold because the, the main Toco Trino, and it is called Delta Toco.
Triano, we call it Delta Gold. And if you go to my website, they say, oh, buying Toko Trino, we. Sell them because we make them in buckets of one ton tote or something like that. So, but we’ll list all the companies that sell them. If you want some names of how you can buy from Amazon. A very strong and good health professional company is Designs for Health.
Designed for health sell this, and they simply just call it Anto e 150 milligram or, or 300 milligram. Now before I pass onto the dosage. I can only mention this in the clinical study. We are not allowed to say it on the bottle. We can send published work. You can go to our website, you can download papers that you can read, or you can download my book here.
To Read Yourself is free. The, when we did a normal person they take anywhere from 100 to 200 milligram depending on their weight. It’s just an antioxidative pro protection. We did it on people 60 to 65 years old at the elderly stage. And if help them in the oxidative protection and then in the.
Pre-diabetes and diabetes study. Mild chronic condition is somewhere between 200 to 400 milligram. And then in studies that we have fatty liver and cancer study, there’s 600 milligram and higher like that. So, but those are very serious condition and when you take it, just remember to take it with a meal.
And I. Before the podcast you asked me the question, so in the instance for people, they may have gut problem, there may be an exception to the rule. You may purposely want to take the toco trinal pill on an empty stomach. That means that only 10, 20% is absorb. 80% or so is not absorbed. So you’ll go to the gut and probably in contact physically on the outside of the body.
To help the colon help, but in all other cases, taking it with a meal will be able to enter systemically .
Awesome. And where can people find you in your
book? They can find me in a book here, Barry, b a r r i e can.com. You’d be able to go, or if you lost that and you simply type my name or American River Nutrition Addict.
Well, thank you so much for being here today. It’s been such a pleasure to have
you. Thank you so much. Hopefully your audience will have a, a, a learning information from this and have a wonderful weekend. Be blessed. You too.
Take care. Bye-bye.
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